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Research
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A |
Animal Care, also here
The UK Division of Laboratory Animal Resources (DLAR) is responsible for
ensuring accountability for animal purchases and required annual
reporting. DLAR maintains background information on animal suppliers,
including documentation of their quality control and animal-disease
status. In addition, appropriate quarantine space, caging, and scheduling
of the clinical laboratory are coordinated by DLAR before animals are
received. Per diem charges are assessed for each animal to cover feeding,
watering, bedding, sanitation, equipment maintenance, veterinary care, and
so forth. The per diem does not include special services such as surgical
care or research-related laboratory testing. The per diem rate varies,
depending upon the species. Designated DLAR Staff members receive and
examine all incoming animals. After the animals have been received, they
are housed in quarantine, and the researchers are notified by electronic
and/or written communication. The quarantine/conditioning period varies
depending upon the species, source of the animals, and type of research to
be conducted. Incoming animals are housed in compliance with the space
recommendations of the Guide for the Care and Use of Laboratory Animals.
DLAR operates a clinical laboratory to support preventative medicine,
diagnostic, and animal definition programs. The laboratory procedures
include blood chemistries, hematology, rodent serologies, bacterial
culturing and sensitivity testing, and parasite identification. DLAR has
four full-time veterinarians who are responsible for animal health and
disease control, along with administrative responsibility. The veterinary
staff is available to all researchers for consultation or assistance. The
Division of Laboratory Animal Resources (DLAR) maintains an Animal Organ
Referral System for researchers who use only one organ or system from a
laboratory animal and are willing to donate tissues to other researchers.
Surgical procedures are performed in the DLAR's Experimental Surgery
facility, a fully staffed sterile animal-operating complex. Appropriate
facilities and equipment are available for postsurgical care. |
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B |
Behavioral
Risk Factor Surveillance System
The BRFSS, the world�s largest telephone survey, tracks health
risks in the United States. Information from the survey is used
to improve the health of the American people. |
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Biostatistics
Consulting Unit
The Biostatistics Consulting Unit, under the direction of Richard Kryscio,
PhD, is a service center of the Kentucky School of Public Health and the
UK Chandler Medical Center. The unit serves the statistical needs of
faculty members, staff, and students and accepts consultations by
appointment. Faculty members in the unit can assist researchers with
virtually every step of the research process, including experimental
design, data entry and management, data analysis, and interpretation of
results. This multidisciplinary unit provides a broad array of
biostatistical and epidemiological consulting services: biostatistical
consulting to investigators on a fee-for-services-rendered basis;
assistance with development of funding proposals, including development of
the experimental design, data analysis, and power analysis sections of
intramural and extramural grants; statistical consulting advice to Medical
Center graduate students doing research projects or dissertations; and
short, noncredit statistics courses for residents, fellows, and faculty
members. |
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C |
Cancer
Prevention and Control
The Markey Cancer Control Program is a multifaceted, comprehensive program
consisting of six collaborative divisions, each of which receives funding
from a variety of sources, including the Centers for Disease Control and
Prevention, the National Cancer Institute, state funds, voluntary health
agencies, and private organizations.
The following are the Cancer Control
Program's six divisions:
- Appalachia Cancer
Network, which addresses cancer issues in rural
medically underserved communities in eight states.
- Cancer
Information Service, which meets the information health needs of cancer
patients, their families, health professionals, and the public.
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Kentucky Appalachian Science Enrichment Program, which provides science
education to students during the summer months.
- Kentucky Cancer
Program, which provides communities and health care professionals across
the state with a comprehensive, science-based cancer control program
through 12 regional offices staffed by cancer control specialists.
- Kentucky Cancer
Registry, which monitors the incidence and mortality
rates associated with cancer in the Commonwealth of Kentucky.
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University of Kentucky Prevention Research Center, the goal of
which is to control cancer in Appalachian Kentucky by defining the
problem, designing interventions, and measuring the impact of
community-based solutions.
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Center for Structural
Biology
This multidisciplinary research center is directed toward the elucidation
of biological functions through the structural analysis of macromolecules.
The center focuses on the structure of proteins, nucleic acids, and
carbohydrates assisted by sophisticated computational analysis and
molecular modeling. This is a central, interdisciplinary facility that
operates a Rigaku x-ray beam generator and detector and high-resolution
graphics workstations for molecular modeling data processing and analysis.
Trained staff are available to provide information on sample preparation,
instruction on the use of facility instrumentation and advice on all
aspects of data analysis. X-ray crystallographic data (Brookhaven and
Cambridge Data Banks) can be accessed directly from the facility via
Ethernet. The center is a founding member of the Southeast Regional
Synchrotron Consortium, a group that owns and operates an X-ray
crystallography data collection facility at the Advanced Photon Source
located within Argonne National Laboratory. This synchrotron radiation
beamline, one of the most powerful in the world, is optimized for
high-throughput data collection and difficult crystallographic problems.
The Center runs two cores, a Tissue Culture and Protein Production Core
and a Proteomics Core. |
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Center
of Membrane Sciences
The Center of Membrane Sciences was established to foster
multidisciplinary research on biological and synthetic membranes and their
interface. The center provides scientific and technological leadership and
facilities to develop basic research in a new generation of membranes and
to promote partnerships fundamental to knowledge and to technology
transfer. As one of only a small number of academically based Centers of
Membrane Science, the UK center has already received international
recognition as a focal point of research among biological and synthetic
membrane experts. Its faculty members, who come from the colleges of Arts
and Sciences, Engineering, Pharmacy, Agriculture, Medicine, and Human
Environmental Systems, compose multidisciplinary research teams who work
to develop new areas of integrative membrane research and to respond to
intriguing challenges of membrane sciences and technology. The center's
strengths in the interface of biological and synthetic membranes are
bolstered by the availability of diverse state-of-the-art research
equipment and facilities for the fabrication and characterization of a new
generation of membranes. Research activities cover a wide spectrum of
topics associated with biological, synthetic, and specialized
biofunctional membranes, including membrane structure-function
relationships, low-pressure reverse osmosis membranes, pollution control,
biosensors, separations, enzyme-based reactive membranes, membrane-based
synthesis of radiopharmaceuticals and specialty chemicals, microspheres,
liposomes, drug-delivery systems, polymer chain interactions,
polymer-substrate interactions, protein absorption to polymeric surfaces,
food preservation, farm animal reproduction, renal physiology, and
neurochemical basis of behavior. Structural studies employ high field NMR,
ESR, ATR-FTIR, and dielectric relaxation spectroscopy, among others, and
use a Langmuir-Blodgett film balance. |
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Chandler
Medical Center
The UK Chandler Medical Center encompasses UK
Hospital and UK Children's
Hospital; the Colleges of
Medicine, Dentistry, Nursing,
Pharmacy, and Health
Sciences; the School of Public
Health; and multidisciplinary centers such as the Markey
Cancer Center and the Sanders-Brown
Center on Aging. Also included under the Medical Center umbrella are
five Kentucky Clinics: three in Lexington and cancer treatment centers in
Berea and Georgetown. Radiation medicine facilities are located in
Maysville, Morehead, Somerset and Mt. Sterling.
As part of a major academic medical center,
the 473-bed UK Hospital has ready access to a full range of technological,
diagnostic, educational, research and information-retrieval resources. UK
Hospital was named a Magnet Hospital in recognition of the outstanding
nursing care at UK Hospital and UK Children's Hospital. It is the first
hospital in Lexington - and only the 39th of almost 6,000 hospitals in the
nation - to achieve the recognition from the American Nurses Credentialing
Center, a subsidiary of the American Nurses Association.
Recently, the trauma center at UK Hospital
was verified again as a Level I trauma center by the Committee on Trauma
of the American College of Surgeons. As one of only two Level I centers
serving the needs of Kentuckians, UK Hospital provides tertiary trauma
care for Central and Southeastern Kentucky,
UK Children's Hospital opened in 1997 as a
65,000-square-foot, $12 million addition to UK Hospital, housing a 44-bed
inpatient center; a 50-bed Level III neonatal intensive care unit, the
only one in Central and Eastern Kentucky; 11 beds for 23-hour
admissions/observation; a state-of-the-art pediatric intensive care unit;
children's playrooms; and expanded family consultation and waiting rooms.
Inpatient admissions each year total about 6,000.
The UK Markey Cancer Center maintains a
comprehensive and multidisciplinary approach to the diagnosis and
treatment of cancer. With the most up-to-the-minute research in cancer
care and technological advances in prevention and treatment, new ground is
being broken every day. One of the newest additions to the center, the
Mary Lou Whitney and John Hendrickson Cancer Facility for Women houses
multidisciplinary clinics and programs dedicated to providing
compassionate, state-of-the-art care and advanced, creative research to
prevent and cure women's cancers.
The UK
Neurosciences Institute provides revolutionary treatment of
neurological disease, bold new solutions to the prevention and treatment
of strokes, and the most advanced model of the non-invasive Gamma Knife in
the state. The UK
Minimally Invasive Surgery Center brings the most up-to-date surgical
technologies in minimally invasive � or laparoscopic � surgery. The Linda
and Jack Gill Heart Institute at UK provides comprehensive services in
cardiology, pediatric cardiology, and cardiovascular and thoracic surgery.
The Institute, along with the new Center for Advanced Surgery, will be
housed in a new facility to open in early 2004.
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Clinical
Oncology Research Program of the Markey Cancer Center
The Markey Cancer Center's Clinical Oncology Research Program (M-CORP)
is a core resource that facilitates and manages the development,
initiation/activation, conduct, and data management of all types of
clinical oncology studies, including NCI Cooperative Group studies,
investigator-initiated studies, and pharmaceutical company studies.
The functions of this office are to:
- Serve as the primary point of contact
within the University for clinical investigators and clinical trial
sponsoring agencies for oncology studies.
- Assist in the design/development of
novel clinical studies.
- Assist in negotiation of sponsor support
for conduct & completion of individual studies.
- Prepare protocols for presentation to
the IRB and shepherd studies through the necessary institutional
review processes.
- Screen patients for eligibility and
register patients on relevant protocols.
- Arrange and document all study-related
interventions.
- Set up and maintain all study-related
files, complete all study-related information, and enter information
into a computerized database.
- Provide protocol availability and
accrual updates for investigators.
- Coordinate information processing for
quality assurance audits by Sponsoring Agencies.
- Provide protocol availability and
accrual updates for investigators.
- Serve as a coordinating center for
community oncology affiliates performing clinical research utilizing
University of Kentucky oncology protocols.
- Monitor protocol compliance of patients
on study and advise physicians of required studies, treatment
schedules and reports.
- Periodically conduct data management
workshops or in-service training for both university and community
affiliate data managers/nurse oncologists.
Through this office, the Markey Cancer
Center makes available approximately 125 studies for all types of cancer
and, in conjunction with its affiliate institutions, places over 300
patients a year on clinical studies. M-CORP coordinates all institutional
and affiliate activities relating to the Southwest Oncology Group (SWOG),
the National Surgical Adjuvant Breast and Bowel Project (NSABP), and the
Radiation Therapy Oncology Group (RTOG), Cooperative Groups of the
National Cancer Institute. M-CORP serves all oncology patient care areas
of the University of Kentucky Medical Center and the adjacent VA Hospital
as well as the Markey Cancer Center. |
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College of Medicine
The University of Kentucky College of Medicine was established in
1956 and enrolled its first class of 40 students in 1960. Today, 3,000
graduates are counted as alumni. Annually, approximately 800 medical
students, residents, and clinical fellows depend upon the diverse academic
opportunities and experiential training provided by the University of
Kentucky Chandler Medical Center. Graduate education at the master's,
doctoral, and postdoctoral levels is also provided to approximately 350
students each year. The College of Medicine offers a faculty community
composed of approximately 470 clinical and 130 basic science full-time
professors and 589 clinical and 144 basic science part-time professors who
nurture the students' academic experiences, as well as more than 860
community-based faculty members.
The focal point of the College of
Medicine's teaching facilities is the UK
Chandler Medical Center. Modern laboratory and classroom space is the
center of activity for medical students. Clinical education is provided
primarily at the on-site University of Kentucky Hospital, the UK
Children's Hospital, the Kentucky Clinic, and the two divisions of the
Veterans Affairs Medical Center.
The UK Chandler Medical Center comprises
five colleges: Medicine, Nursing, Pharmacy, Dentistry, and Allied Health
Professions. In addition, the Kentucky School of Public Health in the
College of Medicine entered its first class of MPH students in 2000 and
its first class of DrPH students in 2001. College of Medicine faculty
members work in the University of Kentucky Hospital, a 473-bed
comprehensive acute care facility, and in the Kentucky Clinic for
Ambulatory Care to provide care to approximately 375,000 patients each
year. This health care facility offers the highest quality
multidisciplinary education each year to more than 3,500 health
professions students. The dynamic nature of this cooperation, available
only through the combined resources of a major medical center, make unique
and diverse educational experiences possible.
The Kentucky Medical Curriculum of the
College of Medicine provides students with a solid foundation in basic
sciences and with diverse opportunities in primary care, specialty care,
and research in urban and rural settings. Through the many patient care
programs of the UK Hospital, the curriculum affords students extensive
training in a wide range of experiential areas that include the
transplantation programs (bone marrow, kidney, heart, lung, liver, and
cornea), the Lucille Parker Markey Cancer Center, the Trauma Center
Emergency Service, the Burn Unit, the Cardiac Care Unit, Radiation Therapy
Services, the MRI and Spectroscopy Program, and Diagnostic Imaging
Services.
The University of Kentucky College of
Medicine is an integral part of the University of Kentucky campus in the
center of Lexington. The College of Medicine, located on Rose Street, is
adjacent to the other four Colleges of the University of Kentucky Chandler
Medical Center and to its research centers.
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D |
DNA
Repair
Growing evidence confirms that defects or insufficiencies in DNA repair
systems confer increased risks for certain kinds of cancer and aging. This
multidisciplinary program is involved in studies of the molecular
mechanisms used by cells for removing DNA damage; of DNA mismatch repair
and maintaining the integrity of the genome; of the conformational
differences between damaged and undamaged DNA and their interactions with
repair proteins; and of DNA damage-induced mutagenesis and DNA excision
repair. |
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E |
Environmental
Research and Training Laboratory (ERTL)
The Environmental Research and Training Laboratory (ERTL) is a shared-use,
core facility at the University of Kentucky. ERTL�s mission is to
improve environmentally related research by providing researchers and
students access to, and training on, state-of-the-art laboratory equipment
and techniques. ERTL was established in 2002 and features nearly $2
million of new laboratory equipment. ERTL is staffed by three highly
trained and knowledgeable full-time laboratory managers. The facility
provides educational and analytical support for inorganic and organic
chemistry, geochemical cycling, microbiology, and virology by using the
following instrumentation: a semi-volatile gas chromatograph/mass
spectrometer (GC/MS); a volatile GC/MS; a gas chromatograph/electron
capture detector (GC/ECD); a gas chromatograph/flame ionization
detector/thermal conductivity detector (GC/FID/TCD); a liquid
chromatograph/tandem mass spectrometer (LC/MS/MS); a high-performance
liquid chromatograph (HPLC); an ion chromatograph (IC); a total organic
carbon (TOC) analyzer; two infrared spectrometer/mass spectrometer (IR/MS)
systems; an elemental analyzer; an inductively coupled plasma optical
emission spectroscope (ICP-OES); a graphite furnace atomic absorption (GFAA)
system; and a mercury analyzer. Funding for the ERTL facility was provided
by the National Science Foundation�s EPSCoR program (grant #
EPS-0132295) and the Kentucky Council on Postsecondary Education. |
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Experimental
Therapeutics
The experimental therapeutics program in cancer is the result of a
collaborative effort between the Markey Cancer Center and the College of
Pharmacy. The goal is to substantially expand translational research in
cancer drug development and to provide patients with earlier access to
experimental treatment options. Emphasis is placed on the development of
new drugs emanating from the pharmaceutical industry or on investigating
new strategies with existing therapeutic agents. The program has four
primary infrastructure components: a clinical experimental therapeutics
program, a preclinical laboratory, a GLP analytical laboratory with a
pharmacokinetic / pharmaco-dynamic support group, and a pharmacogenetics /
pharmacogenomics laboratory. |
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F |
Flow
Cytometry
This facility provides state-of-the-art analysis and sorting of
single-cell populations for research. The facility offers a Cytomation
MoFlo cell sorter with three lasers and high-speed cell sorting capability
and a Becton-Dickinson FacsCalibur cell analyzer. Researchers can use the
facility's equipment to analyze membrane, cytoplasmic, and nuclear antigen
expression; light-scattering properties; DNA content, cell cycle phases,
and apoptosis; and intracellular biochemical changes such as calcium flux
and pH. |
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G |
Gene
Regulation � DNA
Sequence Facility
This facility has up-to-date computer programs on a Sun workstation to
enable faculty throughout the university to compare DNA or protein
sequences and to analyze and manipulate DNA and protein sequence data for
molecular biology studies involving analysis of protein structure and
function, gene cloning, and gene regulation. |
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General
Clinical Research Center
The UK General Clinical Research Center (GCRC), funded by the National
Institutes of Health, provides an excellent environment for investigations
of the cause, progression, prevention, control, and cure of human disease.
It also provides an optimal setting for controlled clinical
investigations. The GCRC strongly encourages collaboration among basic and
clinical scientists. The goals of the GCRC are to develop, promote, and
maintain a national core of expert clinical investigators; to train other
health care professionals in clinical research; and to provide resources
to advance scientific knowledge that may be translated into new or
improved methods of patient care.
The
GCRC is located in the 5 North wing of the University Hospital
and on the second floor of the Kentucky Clinic. The Center provides
medical scientists throughout the University with the resources necessary
to conduct patient-oriented research. The GCRC also provides research
investigators with services in the areas of administration, core lab
services, data safety and analysis, patient care, and database management.
The GCRC performs the following functions:
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Provides clinical research infrastructure for medical
scientists who conduct patient-oriented research;
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Hosts investigators funded by the NIH and by other federal,
state, and local agencies, as well as by the private sector;
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Provides resources to allow investigators to perform pilot
studies that may lead to funding from other agencies;
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Provides the optimal setting for controlled clinical
investigations;
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Encourages collaboration between basic and clinical
scientists;
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Serves as an environment for training other health
professionals in clinical research;
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Provides resources that advance basic
scientific knowledge
and lead to new or improved methods of patient care.
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H |
Hematologic
Malignancies
Hematology/Oncology faculty members of the University of Kentucky's
Medical Center and the Markey Cancer Center evaluate and manage the full
spectrum of hematologic malignancies. A Blood and Marrow Transplant
program provides high dose-intensity treatment options within a 16-bed
"barrier" environment on the third floor of the Ben F. Roach
Building of the Markey Cancer Center. Procedures provided include
peripheral blood stem cell replenishment after high-dose chemotherapy
treatment or whole-body irradiation; autologous and allogeneic bone marrow
transplantation; partially matched related-donor, T cell-depleted
allogeneic transplants; partially matched unrelated-donor transplants; and
an umbilical cord blood program. Clinical outpatient facilities for the
treatment of hematologic malignancies are based in the newly opened
Whitney-Hendrickson building. Services include chemotherapy, infusion, and
supportive care with an on-site pharmacy. A pediatric hematology/oncology
inpatient unit is based in the University of Kentucky Children's Hospital
on the fourth floor of the Chandler Medical Center, and newly constructed
pediatric outpatient space is housed in the Kentucky Clinic. Clinical
research studies are facilitated through services provided by several
institutional shared resources and core facilities, including the Markey
Clinical Oncology Research Program, the General Clinical Research Center,
two research-based flow cytometry core laboratories for sophisticated
hematologic cell sorting and analysis, and the Medical Center
Biostatistical Consulting Service. A tissue procurement service provides
an essential link between clinical treatment and laboratory-based research
projects. |
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HP
Superdome Complex Supercomputer
The University of Kentucky Information Technology provides
state-of-the-art computing services to all faculty members, students, and
staff members, as well as to members of the National Computational Science
Alliance, a cooperative partnership of academic, government, and industry
researchers engaged in developing and deploying cutting-edge high
performance computing technologies. One of the main efforts of the
Alliance involves the creation of the Access Grid, a collection of high
performance and high throughput resources and services that support both
formal and informal intergroup communication and interaction between
Alliance users. UK is one of the initial sites on the national Access
Grid. The principal large-scale scientific computational facility at UK is
an HP Superdome complex consisting of four SMP servers interconnected by a
high-speed, low-latency "hyperfabric" network, in addition to
gigabit Ethernet links to the public network. Three of the servers in the
cluster have sixty-four PA-8700 processors each, and the fourth has thirty
two PA-8700 processors, for a total of 224 processors (at 750 MHz). The
complex has 448 gigabytes of main memory, 5 terabytes of disk space, and
is rated at 672 peak GFLOPs. UK has been ranked 8th among 27
high-performance academic computing centers in the United States and 109th
among the top 500 supercomputer sites world-wide. Current projects by UK
researchers using the Superdome cluster include computational chemistry,
computational biology, computational fluid dynamics, ocean modeling,
particle physics, protein structure, as well as projects in agricultural
science, astrophysics, engineering, mathematics, pharmacy, and
nanotechnology. |
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I |
Imaging
Facility
The Imaging Facility is a multi-use facility available to all faculty
members, staff members, and students at the University of Kentucky on a
fee-for-service basis. The facility contains a central preparatory
laboratory for light microscopy and transmission electron microscopy,
photographic darkrooms, an ultrastructural sectioning room, and individual
rooms for laser scanning confocal microscopy, transmission electron
microscopy, and a PC workstation for image review and printing of confocal
and electron microscopic images. |
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L |
Lexington
The Kentucky city known today as Lexington is located near
Harrodsburg, site of the first settlement west of the Allegheny Mountains,
and Boonesborough, established in 1775 by Daniel Boone. Lexington was
established in an area known as McConnell Springs and was named after
Lexington, Massachusetts, site of the opening battle of the Revolutionary
War. Lexington is located in Fayette County, named in 1780 in honor of the
Marquis de Lafayette, the most famous French supporter of the American
Revolution. Lexington was originally a part of Virginia, but in 1782 the
Virginia Assembly granted the town 710 acres, and in 1792 Kentucky became
a state in its own right, with Frankfort as its capitol. The city is the
home of Transylvania University, founded in 1780 as the 16th college in
the United States and the first west of the Alleghenies. The school of
medicine at Transylvania was one of the first five in the United States;
it closed in 1860. Lexington's most famous citizen was probably Henry
Clay, who built his estate in the city in 1812. By the early 1900s,
Lexington had become the world's largest burley tobacco market. In 1924,
William Monroe Wright, founder of Calumet Baking Powder, joined a number
of horse farms to form Calumet, home of eight Kentucky Derby champion
Thoroughbreds. Keeneland Race Course opened near Calumet in 1936.
Because Lexington houses two nationally
renowned universities, the city offers many urban amenities just minutes
from beautiful horse farms with their white fences and rolling
countryside. Lexington's arts and cultural scene includes the Lexington
Philharmonic, the Lexington Children's Theatre, Broadway Live, the
Lexington Ballet Company, and the Ballet Theatre of Lexington. History
enthusiasts can take in centuries of change at Henry Clay's Ashland, the
Mary Todd Lincoln Home, the Hunt-Morgan House, the Bodley-Bullock House,
and the Waveland mansion. The region's unemployment level is low, the cost
of living is affordable, and the schools are excellent. The city has
experienced sustained growth over the past 10 years, with new shopping
complexes, additional manufacturing companies, and e-commerce strength.
Lexington also offers exciting sports activities, including the University
of Kentucky's seven-time national championship basketball team and the
Lexington Legends, a Single-A baseball team that won its league
championship in its first year of existence. |
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Lucille P.
Markey Cancer Center � Research Resources
See Research Resources of the Lucille
P.
Markey
Cancer Center. |
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M |
Magnetic
Resonance Imaging and Spectroscopy Center
The Magnetic Resonance Imaging and Spectroscopy Center (MRISC) is a
service center supporting basic and clinical research at the University
of Kentucky. The
Center includes an advanced 1.5T Siemens Magnetom Vision scanner with
high-performance gradients, echo-planar whole-body imaging, and
multinuclear spectroscopic capabilities for both human and animal studies.
Also available are computing facilities, electronic and fabrication shops,
and a multiuser laboratory available to support magnetic resonance and
spectroscopy studies. Scientific and technical personnel are available to
help in developing MR sequences and procedures and to help with image
processing analysis. The mission of the Center is to support MRI and
spectroscopy research at the University. To accomplish this mission, the
Center has three specific goals:
-
To
facilitate research use of advanced MRI and spectroscopy
instrumentation by students and faculty, including actively recruiting
new users and developing new applications
-
To
continue to upgrade and improve the instrumentation and software in
the Center
-
To
provide the best user-oriented research support services at the lowest
costs possible, consistent with maintaining fiscal responsibility
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Mass
Spectrometry Facility
The UK Mass Spectrometry Facility (UKMSF), located in the Advanced Science
and Technology Commercialization Center (ASTeCC), is home to an impressive
array of mass spectrometers. UKMSF provides analysis through many
different methods of sample introduction, ionization, and mass
measurement. Mass spectrometric methods are applicable in characterizing
compounds originating from organic and organometallic synthesis, isolation
of natural products, and analysis of pharmaceuticals and their
metabolites. The facility is also involved in characterization of high
molecular weight biologic compounds such as peptides, proteins,
oligonucleotides, complex lipids, and carbohydrates, as well as synthetic
polymers, by methods such as MALDI and ESI. |
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N |
Nuclear
Receptors
Under the leadership of Dan Noonan, PhD, associate professor in the
Department of Molecular and Cellular Biochemistry, UK scientists are
conducting a multifaceted research program directed at understanding the
mechanism(s) by which steroids and other lipophilic hormones and
xenobiotics mediate both normal and carcinogenic pathways. Steroid/nuclear
receptors, upon interaction with their cognate ligand, bind DNA. Both the
rate and the pattern of gene expression mediated by DNA-bound receptor
appear to be dictated by a complex of coregulatory proteins that bind the
receptor and interact with basal transcription complexes. Recent studies
have identified several novel coregulators of steroid/nuclear receptor
family members. These coregulatory proteins appear to directly affect the
ability of cells to respond to hormonal stimulation at both the gene
expression level and the cell proliferation level. Additionally, results
show that mutation of at least one of these proteins (tuberin) directly
affects the pathology of tuberous sclerosis, an often fatal disease marked
by abnormal cellular proliferation and migration, and of
lymphangioleiomyomatosis, a rare but fatal female-specific lung cancer.
Current studies are aimed at resolving the mechanism(s) by which these
steroid receptor coregulatory proteins affect gene expression and cellular
proliferation. To this end, researchers use state-of-the-art molecular,
cellular, and structural analyses aimed at delineating the intracellular
signaling pathways that these coregulatory proteins help to define,
determining their role in the pathogenesis of these diseases, and
discovering potential therapeutic targets for disease intervention. |
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O |
Office
of Research Integrity (ORI) also here
ORI guides the university in developing and implementing policies and
procedures that ensure compliance with federal requirements for the
ethical conduct of research. ORI provides administrative assistance to
three medical Institutional Review Boards and one nonmedical Institutional
Review Board (IRB) for the protection of human research subjects; to the
Radioactive Drug Research Committee (RDRC); and to the Institutional
Animal Care and Use Committee (IACUC). ORI also advises faculty members,
staff members, and students about university and federal regulations;
disseminates IRB, RDRC, and IACUC application forms; prepares and
maintains federally mandated reports; and assists in handling IRB, IACUC,
and RDRC reports of noncompliance. ORI also supports the institution in
promoting ethical conduct of research and educating UK students and
employees about research misconduct regulations. |
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Office
of Sponsored Projects Administration (OSPA) also here
OSPA submits extramural proposals and receives and administers grants and
contracts for research, instructional, and service activities. OSPA
assists faculty members with budgets and other business requirements of
funding proposals; receives, reviews, and negotiates changes to awarded
grants and contracts; serves as a source of information on grant or
contract procedures and regulations; and prepares contractual documents
when outside consultants and subcontractors are required. The unit also
serves the administration of the university by implementing policy
decisions affecting grants and contracts; by protecting the university's
interests in interactions with sponsoring agencies and internal review of
grant or contract matters; and by providing information concerning
proposal and award activity. |
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Ovarian
Cancer Screening Program
Ovarian cancer
is a curable cancer that must be detected early if extended survival is to
be achieved. The OVarian CAncer REsearch (OV-CARE) program is an
early-detection trial that offers free annual screening by transvaginal
ultrasound, which detects virtually all small ovarian cancers. The mission
of the program is to reduce deaths due to ovarian cancer in the group that
is screened. The program is open to
women who are at least 50 years old or women who have a risk evaluation
equivalent to that of a 50-year-old woman. Thus far, more than
19,000 participants have received more than 85,000 free screening
procedures in this program (more than 800 screening procedures have been
performed per month). Preliminary results indicate that such screening
reduces ovarian cancer deaths in the group screened. |
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Oxidative
Stress
The Markey Cancer Center program in oxidative stress investigates the
fundamental mechanisms by which reactive oxygen species and reactive
nitrogen species contribute to normal tissue injury and cancer formation.
The ultimate goal of this multidisciplinary program is to develop novel
strategies for intervention and improved treatment. Research areas include
transcriptional regulation of the human manganese superoxide dismutase (MnSOD)
gene; redox-mediated mechanisms of tumor suppression; antioxidant
protective mechanisms against cardiac and neuronal injury; suppression of
radiation-associated transformation; interaction of reactive intermediates
of environmental toxins with heme- and flavin-containing enzymes; the
effects of polychlorinated biphenyl compounds on the induction of
oxidative DNA damage; the engagement of peroxisomes and characterization
of a small family of intracellular receptors that can be activated by
peroxisome proliferators. |
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P |
Proposal Development Office (PDO)
PDO assists faculty members in securing extramural funding to
support their scholarly activities. Specific services include
disseminating announcements about funding opportunities; identifying
potential funding sources; serving as a liaison to funding agencies;
assisting individuals and groups of faculty members in developing programs
and proposals; conducting seminars on securing grants and on funding
strategies; conducting new faculty orientations; and coordinating
multidisciplinary research proposal submissions. |
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Proteomics
Facility
The Proteomics Facility is part of the University of Kentucky Mass
Spectrometry Facility, located in the Advanced Science and Technology
Commercialization Center (ASTeCC). By using gel electrophoresis and mass
spectrometry, the Proteomics Facility determines protein structure from
enzymatic digests.
The
Proteomics Facility is designed to provide quantitative and qualitative
protein profiling and identification analysis, as well as
post-translational modification and sequence analysis through a
combination of 2D gel, mass spectrometry, and Edman sequencing analysis
services. The facility is equipped with a Bio-Rad immobilized pH gradient
(IPG) and sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
apparatus for 2D gel analysis; a Typhoon phosphorimager/scanner system for
detection and quantitation of fluorescent protein dyes (Cy-dyes) and
stains (SYPRO-Ruby, Pro-Q Diamond) used to analyze 1D and 2D gels; a
Ciphergen SELDI-TOF protein profiling system; an ABI QSTAR II Q-TOF mass
spectrometer with both MALDI and LC/ESI source capabilities; an ABI
Procise 4 column Edman pulsed liquid phase sequencer; Waters
high-performance liquid chromatography (HPLC) systems; and multiple PCs
for data acquisition and analysis, including a site license for PDQuest
software and a 5-station site license for Ciphergen software. The fully
trained technical staff assists investigators with the full range of
proteomics analytical services. Protein fragmentation, mass peptide
mapping, and protein sequencing by both tandem mass spectrometry (MS/MS)
and chemical sequencing are performed on samples provided by individual
investigators. Preparation and analysis of samples with the Ciphergen
system are facilitated by automated robotic work stations. Data analysis
is performed by investigators and their colleagues through multiple
distant work stations connected to the Ciphergen system via the Web.
The
Proteomics Facility performs all aspects of Ciphergen analysis with
samples provided by investigators. Samples are applied to protein chips,
and the Chips are washed and prepared for SELDI-TOF analysis by using the
automated BioMek workstation and the protocols and reagents supplied by
the manufacturer. Chips are currently available with anionic (WCX2, CM10),
cationic (SAX2) or hydrophobic surfaces (H10) for capturing complementary
protein complements. Affinity capture techniques using chips possessing
immobilized metal chelates (IMAC3, IMAC40) or chemically reactive (PS20,
PS-10) surfaces are also available. The latter can be used to generate a
variety of useful capture surfaces, including those containing small
molecules such as biotin or glutathione as well as those with specific
proteins of interest (e.g., antibodies). Thus, a substantial range of
discrimination is possible with regard to components being analyzed.
The
Proteomics Core is located in four separate laboratories on the 6th
floor of the Medical Sciences wing of the College
of Medicine,
contiguous with most of the Department of Molecular and Cellular
Biochemistry. One of the laboratories houses the ABI Procise Edman
sequencer; the ABI QStar XL mass spectrometer and related equipment in
located in the adjacent laboratory. The Ciphergen Protein Profiling System
is housed in a dedicated laboratory with no other equipment. The 2D gel
analysis equipment is housed in the fourth lab, together with a dedicated
computer system for quantitative gel comparison. The total space dedicated
to this core is ~ 1000 nsf. |
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R |
Research
Resources of the Lucille P.
Markey Cancer Center
The Markey Cancer Center functions as a multidisciplinary
"matrix" center within the University of Kentucky, with an
overall mission to foster and facilitate advances in the prevention, early
detection and management of cancer. Operating with a small core of staff
scientists, its programs, overall, engage a total of over 150 faculty in
29 departments of 8 different college of the university.
The physical facilities of the Center house
a number of core facilities, including: Transgenic Mouse Construction,
high-field NMR spectroscopy and Molecular Modeling, a Clinical Oncology
Research Office, a specialized "barrier" animal care facility, a
shared cell culture facility and a human hematopoietic cell processing
facility. In addition, the center houses a Molecular Dynamics
Phosphoimager, a BiaCore analysis system, Beta, Gamma and Top-Count
radioisotope counters, spectrophotometers, Dupont-Sorvall preparative,
high-speed and ultra-centrifuges, a digital photography system, and a
glassware washing and sterilization facility.
Beyond the cancer center, the organization
supports a Fluorescence Activation and Cell Sorting facility and a Tissue
Procurement and Banking Service.
The center also offers a variety of pilot
project funding resources for novel cancer-related research, as well as
grant preparation assistance for interactive and program project grants.
The unique Cancer Prevention and Control
Division of the center offers a number of extended services. The Kentucky
Cancer Registry, now an integral component of the NCI-SEER program, tracks
data on all cancer cases in Kentucky (approximately 20,000 new cases per
year) with a reference activation date of 1991. The Cancer Information
Service, also NCI-based, provides information and educational services,
community outreach and research support services for the entire Mid-South
region. A Prevention Research Center offers partnerships in research and
demonstration projects in cancer surveillance and prevention throughout
Kentucky.
Programmatically, the center highlights and
supports the coordination of a number of areas of special emphasis,
including: Organ-based programs in Breast, Gynecologic, Lung,
Gastrointestinal, Genitourinary, Head & Neck, Hematologic and Brain
cancer. Other cross-disciplinary programs include: Cellular &
Molecular Biology; Signal Transduction; Oxidative Stress; Nuclear
Receptors; DNA Repair & Carcinogenesis/ Tumorigenesis; and Cancer
Prevention & Control.
These combined resources support a broad
spectrum of molecular, cellular, animal, human and behavioral/epidemiology
studies for the advancement of the overall mission. |
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S |
SCID
Mice
At the University of Kentucky, mice are housed primarily in the Combs
vivarium and Central Animal Facility (CAF). The animal care and use
program has been continuously accredited by AAALAC since 1966; these
facilities have been part of that accreditation since opening in 1989. The
facilities house nude mice, SCID mice, transgenic mice, knockout mice and
conventional mice. All mice are SPF, with verification of a clean health
status required before receipt of non-vendor mice. Quarterly sentinel
evaluations are performed. Specialized rooms are available for BL2
research.
Primary enclosure for rodents is standard
polycarbonate or polythenylsulfone shoebox caging with Micro-Isolator
tops. Additional enclosures for mice include polysulfone Pressurized
Individually Ventilated (PIV) shoebox caging system by Tecniplast USA. In
order to provide maximum protection of the mice from mouse pathogens, mice
are treated and cages changed in laminar flow, HEPA-filtered biosafety
cabinets. A small number of mice that are used in specialized experiments
may be housed in open cages, in rooms isolated from Combs and CAF. Mice
are group housed, allowing visual, tactile, auditory, and olfactory
stimulation (fighting males are an exception to this policy). Chew type
enrichment materials are provided for the mice. All animals are provided
food and water, ad libitum, with the exceptions of IACUC approved
food/dietary control.
Combs and CAF are served by two dedicated
HVAC systems that provide l00% coarse filtered, fresh air to all rooms at
a rate of 10-15 air changes per hour. The laminar air flow Aclean rooms in
the Combs Cancer Research Facility (CB14, CB16, CB17, CB19, CB20, and
CB22) and the Central Animal Facility (MA 68, Ma 69, MA 71, MA 73, MA 75)
have approximately 150 air changes per hour, with 20% fresh air input and
HEPA filtration.
Humidification is zonal, and maintained
between 30% and 70% relative humidity. Each room is individually
temperature controlled at preset points, +2o, in the range
appropriate for the species. Maximum/ minimum thermometers in rooms are
monitored daily by animal technicians. This system is on diesel generator
emergency power.
All animal room lights are fluorescent and
timer-controlled operated. The average illumination is 30-40 foot candles
at five feet above the floor (verified by a data logger manufactured by
Edstrom, which is placed in each animal room for a minimum of 24 hours
once a month). There are no exterior windows in any animal rooms.
The University of Kentucky IACUC provides
review and approval for all animal care and use proposals at the
University of Kentucky, regardless of the area of research. A staff of
four veterinarians, headed by an ACLAM diplomate, oversees daily medical
and humane care in Combs and the CAF. Twnety-four hour emergency care is
provided year round. |
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Specialized
Animal Care also here
The UK Division of Laboratory Animal Resources (DLAR) is responsible for
ensuring accountability for animal purchases and required annual
reporting. DLAR maintains background information on animal suppliers,
including documentation of their quality control and animal-disease
status. In addition, appropriate quarantine space, caging, and scheduling
of the clinical laboratory are coordinated by DLAR before animals are
received. Per diem charges are assessed for each animal to cover feeding,
watering, bedding, sanitation, equipment maintenance, veterinary care and
so forth. The per diem does not include special services such as surgical
care or research-related laboratory testing. The per diem rate varies,
depending upon the species. Designated DLAR Staff members receive and
examine all incoming animals. After the animals have been received, they
are housed in quarantine, and the researchers are notified by electronic
and/or written communication. The quarantine/conditioning period varies
depending upon the species, source of the animals, and type of research to
be conducted. Incoming animals are housed in compliance with the space
recommendations of the Guide for the Care and Use of Laboratory Animals.
DLAR operates a clinical laboratory to support preventative medicine,
diagnostic and animal definition programs. The laboratory procedures
include blood chemistries, hematology, rodent serologies, bacterial
culturing and sensitivity testing, and parasite identification. DLAR has
four full-time veterinarians who are responsible for animal health and
disease control, along with administrative responsibility. The veterinary
staff is available to all researchers for consultation or assistance. The
Division of Laboratory Animal Resources (DLAR) maintains an Animal Organ
Referral System for researchers who use only one organ or system from a
laboratory animal and are willing to donate tissues to other researchers.
Surgical procedures are performed in the DLAR's Experimental Surgery
facility, a fully staffed sterile animal-operating complex. Appropriate
facilities and equipment are available for postsurgical care. |
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Survey
Research Center
The University of Kentucky Survey Research Center conducts research of
social pertinence with public policy implications, as well as research of
theoretical or academic pertinence. The Center has conducted more than 450
studies since its establishment in 1979. The Center's client base includes
local and state government agencies, private and nonprofit groups, and
university researchers. The Center provides the expertise, resources,
facilities, and staff for research using telephone surveys, face-to-face
interviews, Web surveys, and mailed questionnaires. Staff members with
graduate-level degrees in political science, economics, social psychology,
public administration, business management, and marketing provide
expertise in survey and questionnaire design, sampling, computer
technology, and advanced statistical methods. The program uses the
WinQuery Computer-Assisted Telephone Interviewing (CATI) system and a
34-workstation call center. This software package is also available on
laptop computers for field research. Computer-Assisted Personal
Interviewing (CAPI) and Computer-Assisted Self Interviewing (CASI) ensure
data quality by reducing interviewer bias. For telephone surveys, the
center uses a modified, list-assisted Waksberg random-digit-dialing
procedure. |
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T |
Tissue Culture and
Protein Production Core
The Tissue Culture and Protein Production Core, run by the Center for
Structural Biology, is designed to facilitate cell culture and recombinant
protein production by its users. It has available well-maintained
equipment and instrumentation not normally found within individual
laboratories including fermentors, bioreactors, cell cracking equipment,
and chromatography for production of recombinant proteins. Instrumentation
to characterize recombinant proteins such as a Circular Dichroism
instrument, fluorometer and light scattering instrument are available in
the Core. A staff member maintains the Core equipment and provide training
to new users. |
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Tissue
Procurement Service of the Markey Cancer
Center
The Tissue Procurement Service (TPS) of the Markey Cancer Center
was established in July 1995 to supply well-characterized human tissues
for peer-reviewed investigations in cancer. This service is provided by
the Division of Surgical Pathology at the University of Kentucky Medical
Center (UKMC), with headquarters in Room HC204 of the surgical pathology
suite. All surgical and biopsy specimens generated at UKMC pass through
this 1,600 square foot facility. The only tissues made available for
research purposes are those that would normally be discarded, i.e., those
that exceed the amount of tissue required for diagnosis. However, despite
this restriction, ample material is usually available for supported
research projects.
Equipment
available within the TPS includes a CBS liquid nitrogen freezer, series
1500, which can store 9,100 specimens (2 ml each), and a Revco upright
freezer (-80�).
Record keeping is managed with a dedicated Dell laptop computer. The TPS
technician carries a beeper and is available during normal working hours.
The
Director of the TPS, Michael Cibull, MD, is also the Director of Surgical
Pathology; this arrangement markedly facilitates the procurement and
processing of tissues needed for research. Prospective resource users
submit written requests for tissues by using a standardized request form.
This form elicits specific information about the kind and amount of tissue
needed and about processing specifications. In addition, the destination
of the tissue is specified, and IRB approval or exemption is documented
before the request is processed. Moreover, the request form notifies the
user that cost recovery will be required and that requests for funding
should be part of any grant application projecting the use of human tissue
through this mechanism.
The
TPS acquires fresh tissue from surgical pathology (or from the autopsy
service or other clinical laboratories, as appropriate) and performs
initial processing, such as snap freezing, freezing in OCT frozen tissue
matrix, and sterile handling, according to the instructions of the
requesting investigator. The tissue is then either delivered directly to
the requesting laboratory or stored in the -80� freezer or in a liquid nitrogen immersion freezer for later
batch distribution. Each specimen obtained by the service is identified by
a unique number separate from the surgical pathology number so that
patient confidentiality is maintained.
Day-to-day
operation, including all tissue procurement, processing, and delivery, as
well as all routine record keeping, is the responsibility of the facility
technician, who is under the direct supervision of Dr. Cibull. Scheduling
is done on a first-come/first-served basis, except in the most unusual
circumstances.
Tissue
taken for research is cross-referenced with demographic information by
using the unique identifying number. In this way, the opportunity exists
to obtain follow-up information, when necessary, using both the
hospital-based and the state tumor registries in conjunction with
information available in the tissue bank database.
An
Advisory Committee, consisting of users plus the head of Surgical
Oncology, provides oversight and evaluation of the facility. Dr. Cibull
and the TPS technician review all tissue requests for appropriateness for
each study and establish a plan for collection and distribution of tissue. |
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Transgenic
Mouse Facility
The Transgenic Mouse Facility (TMF) provides a state-of-the-art approach
to the introduction of recombinant DNA molecules into the mouse germline
via microinjection. TMF personnel advise researchers about methods of
preparing DNA for microinjection and transgenic mouse analysis.
Researchers supply the facility with recombinant DNA in a form suitable
for microinjection. A trained technician performs all surgical and
microinjection procedures. The laboratory is equipped with a Nikon
Diaphot-TMD microscope with a Hoffman modulation contrast optic system and
two Narashige micromanipulators. The facility also offers cryopreservation
of mouse sperm and rederivation of cryopreserved mouse lines. |
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U
|
University
of Kentucky
Founded in 1865 as a land-grant institution, and adjacent to downtown
Lexington, the University of Kentucky (UK) is nestled in the very heart of
the beautiful Kentucky Bluegrass region. From its early beginnings, with
only 190 students and 10 professors, UK's campus now covers more than 687
acres and is home to more than 34,000 students and nearly 12,000
employees.
UK is one of only a few universities in the
country with a teaching and research campus, a medical center, and a
community college all in one central location. The state's flagship
university consists of 15 academic and professional colleges in which
students can choose from some 200 majors and degree programs. The colleges
are Agriculture, Arts and Sciences, Business and Economics, Communications
and Information Studies, Dentistry, Design, Education, Engineering, Fine
Arts, Health Sciences, Law, Medicine, Nursing, Pharmacy, and Social Work.
UK's student body is diverse, representing
117 countries, every state in the nation, and every Kentucky county.
Admissions are selective, and UK ranks among the top 50 universities in
the annual U.S. News & World Report survey. The university also
attracts excellent students. The average ACT score for first-year students
is four points above the national average. In 2003, UK earned a spot among
the top 15 public universities in enrolling new freshman National Merit�
Scholars, placing the university 35th among both public and private
institutions. Students compete successfully for prestigious scholarships
and awards, such as the Fulbright, Truman, Goldwater, and Marshall. In
2002, UK was selected as one of only 13 universities nationwide to
participate in the Beckman Foundation Scholarship program. This program
allows UK to award grants of $17,600 to students to support their own
research projects.
Since the mid-1990s, the University has
pursued an ambitious goal of becoming a top-20 public research university
by the year 2020. UK President Lee T. Todd Jr. has embraced this goal, and
the university is working aggressively to achieve it. During the last
fiscal year, UK faculty members received a total of $212 million in
extramural grants and contracts, a 22 percent increase over the previous
year. These numbers place the university 52nd on the National Science
Foundation's list of all institutions and 36th among public universities.
UK boasts more than 80 national rankings for academic excellence. The
College of Pharmacy, the Martin School of Public Policy and
Administration, the College of Law, and the College of Medicine are highly
ranked in U.S. News & World Report's rankings of the best graduate
schools. The College of Pharmacy is third, and the Martin School is ranked
fifth in the category of public finance and budgeting. The College of Law
is ranked among the top 25 law schools at public institutions, the College
of Medicine's Rural Medicine program is ninth, and the College of Nursing
is ranked 29th.
With its well manicured landscape and
landmark buildings, UK's campus also offers great facilities that advance
the scholarship of its students and the research endeavors of its faculty.
The William T. Young Library, only five years old, is among the world's
leading research libraries; its book endowment is the largest among public
universities and ranks second only to Harvard University among all
universities. Its broad scope of technology offers students, faculty
members, and Kentucky residents special access to the most up-to-date
information from online journals, government publications, and private
studies, as well as more traditional materials.
Research at the University of Kentucky is a
dynamic enterprise encompassing both traditional scholarship and emerging
technologies. In more than 50 research centers and institutes, UK
researchers are discovering new knowledge, providing a rich training
ground for the next generation of researchers, and advancing the economic
growth of the Commonwealth of Kentucky. Several centers excel in the
services offered to the public. The Center for Manufacturing Systems has
assisted more than 500 small and mid-sized industrial firms throughout the
state. The Gluck Equine Research Center is one of only three facilities of
its kind in the world, conducting research into diseases of the horse.
Because UK is one of the few universities
in the country with a research and teaching campus and a medical center in
one central location, multidisciplinary research is particularly strong.
The ASTeCC (Advanced Science and Technology Commercialization Center)
building in the center of campus provides laboratory space for faculty
affiliates who represent a variety of colleges and departments and is a
hub for multidisciplinary research collaboration and commercialization. UK
researchers engage in projects with professors at the University of
Louisville, Murray State University, Eastern Kentucky University, and
other public and private institutions across Kentucky, in other states and
abroad.
The University of Kentucky Chandler Medical
Center was established on the campus of Kentucky's flagship university in
1957 and is one of the nation's finest academic medical centers. The
faculty, students, and staff of our young, dynamic Medical Center take
pride in achieving excellence in education, patient care, research, and
community service. The 473-bed UK Hospital and UK Children's Hospital are
supported by more than 500 faculty physicians and dentists, 400 resident
physicians, and a staff of 3,200 health professionals committed to
high-quality patient care. As the only Level 1 Trauma Center in Central
and Eastern Kentucky, UK Hospital and UK Children's Hospital care for the
most critically injured and ill patients in this half of Kentucky.
UK is reaching out to communities across
the Commonwealth, sharing knowledge and making a difference in the towns,
cities and lives of all Kentuckians. An example is Health Education
through Extension Leadership (HEEL), a new partnership between the College
of Medicine, its School of Public Health, the College of Agriculture, and
the Cooperative Extension Service. HEEL was created to enhance the
Cooperative Extension agents' capacity to deliver valuable health and
wellness information throughout the state. UK also received a $22 million
grant from the National Science Foundation to strengthen and reform
education in math and science in pre-K through grade 12 in Kentucky. The
grant is the largest single grant in the school's history.
UK's agenda is simple. It is to accelerate
the movement toward academic excellence and to become known worldwide for
the quality of its academic programs, its commitment to undergraduates,
its success in building a diverse community, and its engagement with the
larger society. That is what the University of Kentucky is all about. |
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UK Chandler
Medical
Center
See Chandler Medical
Center. |
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UK
Clinical Research Organization (UKCRO)
UKCRO provides clinical and translational research faculty and staff
members with the infrastructure and operational support to facilitate
access by citizens of the Commonwealth to outstanding clinical research
trials. UKCRO is under the leadership of the Assistant Vice President for
Clinical Research, who is responsible for developing and managing clinical
research center activities and for ensuring that the Medical Center's
resources are accessible to all faculty members engaged in clinical
research. UKCRO consists of a Project Initiation/Management Unit, a
Clinical Research Operations Unit, an Outpatient Clinical Research Clinic,
a Clinical Research Marketing Unit, and a Clinical Research Compliance
Unit. UKCRO also provides clinical research education to all faculty
members, staff, and students who participate in clinical research.
The Project Intiation/Management Unit
provides overall project coordination for all clinical research and
assists investigators and their clinical coordinators in preparing and
reviewing all documents necessary for the initiation and approval of the
research contract. This unit also provides research project services such
as a designated project coordinator, coordination of external monitors and
close-out visits, a regulatory binder, IRB correspondence, study budgets,
research nurse coordinators, adverse event submission, and preparation of
Investigational New Drug (IND) applications.
The Clinical Research Operations Unit
focuses on the operation of clinical research inpatient and outpatient
units. This unit assists in recruiting patients, completing Case Report
Forms, ensuring fiscal and regulatory compliance, reconciling patient
charges, and ensuring appropriate changes to project budgets. The
Inpatient Clinical Research Unit works with project coordinators to ensure
clinical completion of the protocol; assists with patient recruitment,
completes source documents and case report forms, and ensures fiscal and
regulatory compliance. The Outpatient Clinical Research Clinic assists
investigators with inpatient and outpatient research by scheduling
volunteers, ensuring fiscal and regulatory compliance, and ensuring good
clinical management.
The Clinical Research Marketing Unit
concentrates on developing an aggressive marketing plan by managing
newsletters, brochures, and Web sites; staffing booths at national
meetings; and marketing clinical research to the pharmaceutical industry
and clinical research organizations.
The Clinical Research Compliance Unit
ensures fiscal and regulatory compliance with FDA and IRB regulations and
with Good Clinical Practices. The unit audits industry-sponsored trials
for protocol compliance and patient safety and monitors investigational
new drug applications and investigational device exemptions. The unit
provides researchers with a study software program designed to enhance
data collection and monitoring. In addition, the unit ensures that
University and Federal cost accounting standards are followed. |
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UK
College of Medicine
See College of Medicine.
|
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|
UK
MicroArray Core Facility
The DNA Microarray Facility has been operational since July 1, 2001. It
has developed the technology for Affymetrix chips and for custom cDNA
microarrays. |
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UK
Research Foundation
Research leading to new knowledge and the transfer of this new knowledge
through teaching and service are two of the primary responsibilities of
the University of Kentucky. The University of Kentucky Research Foundation
(UKRF) is a not-for-profit Kentucky corporation established to receive,
invest, and expend funds to promote and implement scientific, educational,
and developmental activities at UK. Founded in 1945, UKRF serves as the
university's agent in the receipt of all external grants and contracts,
intellectual property income, and other designated income. UKRF oversees
the protection, development, and commercialization of intellectual
properties and manages special cooperative agreements. |
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